Coming together to solve a series of murders in New York City are a DEA agent whose family was slain as part of a conspiracy and an assassin out to avenge her sister’s death. The duo will be hunted by the police, the mob, and a ruthless corporation.

Blocking out the shadows of his past Max Payne is unexpectedly confronted by former friend and love interest Mona Sax, who reveals vital information that can bring down drug lord Jack Lupino.